ポピュラーベクター Rat Neu4

Predicted to enable exo-alpha-(2->3)-sialidase activity and exo-alpha-(2->8)-sialidase activity. Predicted to be involved in several processes, including ganglioside catabolic process; glycoprotein catabolic process; and negative regulation of neuron projection development. Predicted to be located in several cellular components, including endoplasmic reticulum membrane; lysosome; and mitochondrial membrane. Predicted to be active in cytoplasm; intracellular membrane-bounded organelle; and membrane. Orthologous to human NEU4 (neuraminidase 4). [provided by Alliance of Genome Resources, Apr 2022] Annotation information: Note: Neu4 (GeneID: 316642) is annotated incorrectly on Rnor_6.0 but correctly on Rn_Celera. Annotation of Neu4 on Rn_Celera is supported by synteny with human and mouse and is instead annotated as NEWGENE_1308624 (GeneID: 103690047) on Rnor_6.0. Additionally, the locus annotated as Neu4 on Rnor_6.0 likely represents a duplicate placement of this locus that lacks support by the syntenic region in mouse and human. BLASTing Neu4 NM_001108234.1 and NEWGENE_1308624 XM_006245535.2 against the rat genome (Annotation Release 105) shows best hits to NC_005108.4 on Rnor_6.0 (at locations where Neu4 and NEWGENE_1308624 are annotated) and AC_000077.1 on Rn_Celera where Neu4 is annotated. 2-sequence BLAST of Neu4 NM_001108234.1 against NEWGENE_1308624 XM_006245535.2 shows high sequence identity (66% coverage, 100% identity). BLASTing Neu4 underlying component AC118069.8 against the rat genome shows best hit to NC_005108.4 on Rnor_6.0 where Neu4 is annotated (hitting itself) and where NEWGENE_1308624 is annotated. 2-sequence BLAST of Neu4 underlying component AC118069.8 against NEWGENE_1308624 underlying component AABR07068355.1 shows 99% sequence identity across ~96 kb. [27 Mar 2015]

NM_001108234.1

NP_001101704.1