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VectorBuilderは、遺伝子デリバリーテクノロジー開発・受託製造のグローバルリーダーです。VectorBuilderは、世界中の何千ものラボやバイオテクノロジー/製薬会社から信頼されるパートナーとして、ラボベンチから患者のベッドサイドまで、ライフサイエンス研究から臨床に至る遺伝子デリバリーのニーズを、ワンストップでご提供します。  内容を表示 >>

VectorBuilderはメンケス病の遺伝子治療の医師主導治験をサポートしています
VectorBuilderは世界初のAAV Superbankの構築に40.6億円を出資します
VectorBuilderは総工費600億円の「遺伝子デリバリー研究製造 キャンパス」建設に着手しました
VectorBuilder プレスリリース

VectorBuildeは、遺伝子デリバリーの基礎研究、臨床応用研究を受託サービスを通じてグローバルにサポートしています。当社のイノベーションに関わる最新ニュースはここからご覧いただけます。

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Stromal changes in the aged lung induce an emergence from melanoma dormancy

Nature. 2022. doi: 10.1038/s41586-022-04774-2. IF: 69.504

MARK4 controls ischaemic heart failure through microtubule detyrosination

Nature. 2021. doi: 10.1038/s41586-021-03573-5. IF: 69.504

snRNA-seq reveals a subpopulation of adipocytes that regulates thermogenesis

Products & Services: vector cloning, AAV, shRNA gene knockdown
Nature. 2020. doi: 10.1038/s41586-020-2856-x. IF: 69.504

Convergent somatic mutations in metabolism genes in chronic liver disease

Products & Services: vector cloning, MSCV
Nature. 2021. doi: 10.1038/s41586-021-03974-6. IF: 69.504

Reprogramming roadmap reveals route to human induced trophoblast stem cells

Nature. 2020. doi: 10.1038/s41586-020-2734-6. IF: 69.504

Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis

Products & Services: vector cloning, AAV
Cell. 2021. doi: 10.1016/j.cell.2021.04.037. IF: 66.85

Structural basis for RNA surveillance by the human nuclear exosome targeting (NEXT) complex

Products & Services: vector cloning
Cell. 2022. doi: 10.1016/j.cell.2022.04.016. IF: 66.85

Neutrophil elastase selectively kills cancer cells and attenuates tumorigenesis

Products & Services: vector cloning, adenovirus
Cell. 2021. doi: 10.1016/j.cell.2021.04.016. IF: 66.85

Prenatal interleukin 6 elevation increases glutamatergic synapse density and disrupts hippocampal connectivity in offspring

Immunity. 2021. doi: 10.1016/j.immuni.2021.10.006. IF: 43.474

Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments

Products & Services: vector cloning, MMLV
Cancer Cell. 2022. doi: 10.1016/j.ccell.2022.01.001. IF: 38.585

Mitochondrial cristae-remodeling protein OPA1 in POMC neurons couples Ca2+ homeostasis with adipose tissue lipolysis

Products & Services: vector cloning, AAV9
Cell Metab. 2021. doi: 10.1016/j.cmet.2021.07.008. IF: 31.373

A high-affinity human TCR-like antibody detects celiac disease gluten peptide-MHC complexes and inhibits T cell activation

Products & Services: vector cloning, MMLV
Sci Immunol. 2021. doi: 10.1126/sciimmunol.abg4925. IF: 30.63

Endogenous Retroviral Elements Generate Pathologic Neutrophils in Pulmonary Arterial Hypertension

Products & Services: vector cloning, piggyBac.
Am J Respir Crit Care Med. 2022. doi: 10.1164/rccm.202102-0446OC. IF: 30.528

YAP/TAZ drives cell proliferation and tumour growth via a polyamine–eIF5A hypusination–LSD1 axis

Products & Services: vector cloning, AAV8
Nat Cell Biol. 2022. doi: 10.1038/s41556-022-00848-5. IF:28.213

Modulation of the HIF2α-NCOA4 axis in enterocytes attenuates iron loading in a mouse model of hemochromatosis

Products & Services: vector cloning, adenovirus, CRISPR
Blood. 2022. doi: 10.1182/blood.2021013452. IF: 25.476

A bivalent vaccine containing D614G and BA.1 spike trimer proteins or a BA.1 spike trimer protein booster shows broad neutralizing immunity

Products & Services: stable cell line
J Med Virol. 2022. doi: 10.1002/jmv.27885. IF: 20.693

Hypothalamic dopamine signaling regulates brown fat thermogenesis

Nat Metab. 2019. doi: 10.1038/s42255-019-0099-7. IF: 19.865

The resolvin D1 receptor GPR32 transduces inflammation resolution and atheroprotection

Products & Services: online vector design
J Clin Invest. 2021. doi: 10.1172/JCI142883. IF: 19.456

Paired box 6 programs essential exocytotic genes in the regulation of glucose-stimulated insulin secretion and glucose homeostasis

Products & Services: vector cloning, AAV8
Sci Transl Med. 2021. doi: 10.1126/scitranslmed.abb1038. IF: 19.319

A simple and rapid method for enzymatic synthesis of CRISPR-Cas9 sgRNA libraries

Products & Services: lentivirus, library construction
Nucleic Acids Res. 2021. doi: 10.1093/nar/gkab838. IF: 19.16

Transcriptional super-enhancers control cancer stemness and metastasis genes in squamous cell carcinoma

Products & Services: vector cloning, lentivirus, CRISPR
Nat Commun. 2021. doi: 10.1038/s41467-021-24137-1. IF:17.694

Shisa6 mediates cell-type specific regulation of depression in the nucleus accumbens

Products & Services: vector cloning, AAV5, shRNA gene knockdown
Mol Psychiatry. 2021. doi: 10.1038/s41380-021-01217-8. IF: 13.437

Lung-selective mRNA delivery of synthetic lipid nanoparticles for the treatment of pulmonary lymphangioleiomyomatosis

Products & Services: in vitro transcription
PNAS. 2022. doi: 10.1073/pnas.2116271119. IF: 12.779

Indomethacin-induced oxidative stress enhances death receptor 5 signaling and sensitizes tumor cells to adoptive T-cell therapy

Products & Services: vector cloning, MSCV
J Immunother Cancer. 2022. doi: 10.1136/jitc-2022-004938. IF: 12.469

A Single-Cell Transcriptomics CRISPR-Activation Screen Identifies Epigenetic Regulators of the Zygotic Genome Activation Program

Cell Syst. 2020. doi: 10.1016/j.cels.2020.06.004. IF: 11.091

Identification of natural compounds as SARS-CoV-2 entry inhibitors by molecular docking-based virtual screening with bio-layer interferometry

Products & Services: S protein-pseudotyped lentivirus
Pharmacol Res. 2021. doi: 10.1016/j.phrs.2021.105820. IF: 10.334

Stromal changes in the aged lung induce an emergence from melanoma dormancy

Nature. 2022. doi: 10.1038/s41586-022-04774-2. IF: 69.504

MARK4 controls ischaemic heart failure through microtubule detyrosination

Nature. 2021. doi: 10.1038/s41586-021-03573-5. IF: 69.504

snRNA-seq reveals a subpopulation of adipocytes that regulates thermogenesis

Products & Services: vector cloning, AAV, shRNA gene knockdown
Nature. 2020. doi: 10.1038/s41586-020-2856-x. IF: 69.504

Convergent somatic mutations in metabolism genes in chronic liver disease

Products & Services: vector cloning, MSCV
Nature. 2021. doi: 10.1038/s41586-021-03974-6. IF: 69.504