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NLRP3 inflammasome activation through heart-brain interaction initiates cardiac inflammation and hypertrophy during pressure overload
Preneoplastic stromal cells promote BRCA1-mediated breast tumorigenesis
Schwann cell insulin-like growth factor receptor type-1 mediates metastatic bone cancer pain in mice
Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness
Glioblastoma remodelling of human neural circuits decreases survival
DNp63/p73 drive metastatic colonization by controlling a regenerative epithelial stem cell program in quasi-mesenchymal cancer stem cells
In situ FRET-based localization of the N terminus of myosin binding protein-C in heart muscle cells
PHGDH-mediated endothelial metabolism drives glioblastoma resistance to chimeric antigen receptor T cell immunotherapy
Genetic and pharmacological modulation of DNA mismatch repair heterogeneous tumors promotes immune surveillance
An AAV-CRISPR/Cas9 strategy for gene editing across divergent rodent species: Targeting neural oxytocin receptors as a proof of concept
Plastin 3 rescues cell surface translocation and activation of TrkB in spinal muscular atrophy homeostasis
Dedifferentiation maintains melanocyte stem cells in a dynamic niche
Antibody gene transfer treatment drastically improves epidermal pathology in a keratitis ichthyosis deafness syndrome model using male mice
SERCA2 phosphorylation at serine 663 is a key regulator of Ca2+ homeostasis in heart diseases
Chaperone-mediated autophagy promotes PCa survival during ARPI through selective proteome remodeling
The ion channel CALHM6 controls bacterial infection-induced cellular cross-talk at the immunological synapse
Somatic mutations can induce a noninflflamed tumour microenvironment via their original gene functions, despite deriving neoantigens
A novel ACE2 decoy for both neutralization of SARS-CoV-2 variants and killing of infected cells
Noncanonical role of singleminded-2s in mitochondrial respiratory chain formation in breast cancer
An astrocyte BMAL1-BAG3 axis protects against alpha-synuclein and tau pathology
Stromal changes in the aged lung induce an emergence from melanoma dormancy
Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis
Modulation of the HIF2α-NCOA4 axis in enterocytes attenuates iron loading in a mouse model of hemochromatosis
Prenatal interleukin 6 elevation increases glutamatergic synapse density and disrupts hippocampal connectivity in offspring
Indomethacin-induced oxidative stress enhances death receptor 5 signaling and sensitizes tumor cells to adoptive T-cell therapy