ポピュラーベクター Human PRKCQ

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors. [provided by RefSeq, Jul 2008]

NM_001242413.2; NM_001282644.2; NM_001282645.1; NM_001323265.1; NM_001323266.2; NM_001323267.2; NM_006257.5

NP_001229342.1; NP_001269573.1; NP_001269574.1; NP_001310194.1; NP_001310195.1; NP_001310196.1; NP_006248.1