ポピュラーベクター Zebrafish oaz1b

The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. Several antizyme paralogs have been described in zebrafish. The mRNA for this antizyme is ubiquitously expressed in the embryo and differentially expressed during development from embryo to adult fish. This antizyme appears to share features in common with both mammalian antizymes 1 and 2: like antizyme 1 mRNA, this mRNA contains multiple potential in-frame translation initiation sites; like antizyme 2, this antizyme negatively regulates intracellular polyamine levels by inhibiting ODC activity, but does not stimulate ODC degradation in vitro. [provided by RefSeq, Jan 2015]

NM_194432.3

NP_919413.2