This region encompasses the promoter and 5\' pancreatic enhancer of the paired box 4 (PAX4) gene. Binding by hepatocyte nuclear factor family members and pancreatic and duodenal homeobox 1 may stimulate enhancer activity. This region is negatively regulated by binding of Pax4 to sites several kilobase pairs upstream of the transcription start site. [provided by RefSeq, Jun 2016]
