This region represents two DNase I hypersensitive sites (HSs) that are located 60-62.5 kb upstream of the Hbb-y (hemoglobin Y, beta-like embryonic chain) gene in the beta-globin gene cluster. The -62.5 HS can bind the CTCF transcription factor, but it does not function as an enhancer-blocking element or as a chromatin barrier element in erythroid cells. Chromosome conformation capture assays indicate that this region is an integral part of the beta-globin active chromatin hub in erythroid cells, where it undergoes looping interactions with 3\'HS1, which is located downstream of the beta-globin gene cluster, and this folding further enables interactions between the beta-globin locus control region (LCR) and active beta-globin gene promoters. [provided by RefSeq, Jul 2015]
