他名称ATAC-STARR-seq lymphoblastoid active region 22511
遺伝子の種類biological-region
要約
This region represents regulatory module A of the growth hormone receptor gene. It encompasses the promoters for alternate 5\' end transcript variants V2, V3, and V9. Transcription is positively regulated through association of ETS proto-oncogene 1 and proteins recognizing GAGA sites. This locus also includes an accessible chromatin subregion that was validated as an enhancer based on its ability to activate an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) massively parallel reporter assay (MPRA) in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
