This region, which is located in an intron of the CCZ1 (CCZ1 homolog, vacuolar protein trafficking and biogenesis associated) gene on chromosome 7, can function as an enhancer in human Jurkat T cells. The spatially equivalent or corresponding region in mouse, which is not conserved at the sequence level, can also function as an enhancer in both mouse EL4 and human Jurkat T cells. The chromatin structure of this region represents a histone acetylation island in human T cells based on the diacetylation of histone H3 at lysines 9 and 14. [provided by RefSeq, Nov 2015]
