This element represents a DNase I hypersensitive site located approximately 111 kb upstream of the HBE1 (hemoglobin, epsilon 1) gene in the beta-globin gene cluster. Chromosome conformation capture assays show that the orthologous mouse hypersensitive site is an integral part of the beta-globin active chromatin hub in erythroid cells, where it undergoes looping interactions with 3\'HS1, which is located downstream of the beta-globin gene cluster, and this folding further enables interactions between the beta-globin locus control region (LCR) and active beta-globin gene promoters. [provided by RefSeq, Nov 2015]
